AB36. Three-port laparoscopic radical prostatectomy (LRP) for prostate cancer (PCa)

Transl Androl Urol, Vol 3, Suppl 1 September 2014 www.amepc.org/tau © Translational Andrology and Urology. All rights reserved. corpora cavernous, respectively. Four weeks after surgery, erectile function (EF) is assessed by measuring maximal intracavernosal pressure (ICP), change in ICP, area under ICP curve, and ratio of change in ICP and mean arterial pressure. Both of the PRP and EPC treatment group result in significant recovery of EF, as compare with the vehicleonly group (P<0.05). Histomorphometrically we analyze myelinated axons number of cavernous nerve (CN) and dorsal nerve, collagen type change, number of apoptotic cells, and mRNA expression of caspase-3 and transforming growth factor-β 1 (TGF-β 1) in the corpus cavernosum. The PRP treatment group has a significant preservation of myelinated axons of CNs, reduced the apoptotic index and decreased the mRNA expression of TGF-β 1 in the corpus cavernosum compares with the vehicle-only group (P<0.05). The EPC treatment group shows a higher expression of von Willebrand factor (vWF), endothelial nitric oxide synthesis (eNOS)in dorsal artery than vehicle-only group (P<0.05). The EPCs can be detected in Corpus cavernosum for longer than seven days after injection. In conclusion, PRP injection into the corpus cavernosum increases the number of myelinated axons, EPC injection can recruit the EPCs toward dorsal artery and preserve the smooth muscle cells in the corpus cavernosum. Both of these treatment can facilitate recovery of EF through different mechanism in the bilateral CN injury rat model. They are also potentially to be good medications in the future for the treatment of neurogenic ED after RP.